James Norwood scored twice at the end of each half as the Lions were denied a point at Tranmere Rovers – the hosts running out 2-1 winners at Prenton Park.
Having survived a sustained spell of home pressure that came to nothing early on, Anthony Dudley and Adam Smith had great chances but were denied by home keeper Scott Davies who proved his worth by stopping both efforts.
However, as the Lions grew into the game, their pressure eventually reaped reward when Gavin Rothery’s astute cross from the right was cleared to Danny Boshell who drilled the ball in to the bottom corner from twenty yards out.
Adam Lockwood replaced the injured Danny Hall on 32 minutes and debutant James Hurst came to his new side’s rescue with a timely clearance to deny the home side an equaliser.
But just as it looked as though the Lions would hold out until the break Rovers were given two contentious corners – the second of which saw Norwood’s glance a header past Steven Drench.
The home side began the second half on top but, having weathered the storm, Guiseley went close through Anthony Dudley while substitute Liam Dickinson rippled the side netting with a free-kick.
But a long ball forward set Norwood free down the right hand channel and, when Drench was adjudged to have fouled the Tranmere man, Norwood tucked away the winner from the spot.
~34 Dudley (Brooksby – 80′ )
12 Hall (Lockwood – 33′ )
33 Smith (Dickinson – 67′ )